Villarreal's Mexican midfielder Jonathan Dos Santos will be sidelined for eight weeks after medical tests showed on Saturday that he has sustained a left thigh injury.
The Mexican player was injured during his side's 1-0 victory over Napoli in the first leg of the Europa League round of 32 on Thursday, reports Efe.
Santos's injury is another setback for the Spanish team, who are also suffering the absence of injured midfielder Samu Garcia, who still needs two months to recover.
Villarreal are currently in fourth place in the La Liga with 48 points, five points behind Real Madrid who occupy the third place.