The ill-fated vehicle, carrying nine passengers, was on way to Balatadi area from Vadade in Pithoragarh when it skidded off the road on a sharp turn and fell into the 'khud' in Jhulaghat area last night, police said.
Four of the passengers were killed on the spot and injured were rushed to a hospital in Pithoragarh.
One passenger of the jeep escaped unhurt, they said.
Uttarakhand Chief Minister Vijay Bahuguna has expressed grief over the accident and asked the administration to provide best medical care to those injured, sources said.
The deceased, identified as Gopal Chandra, Deewan Chandra, Rajendra Chandra and Mohan Chandra, were locals.
