Nupur, who surrendered in the court of Special CBI Magistrate Priti Singh, was immediately taken into custody by the agency.
Her lawyer R K Saini moved the court for Nupur's bail but the Magistrate reserved the order for two hours, during which the agency will also file its reply.
Nupur, who was accompanied by her husband Rajesh Talwar, was seen reciting 'Hanuman Chalisa' in the court room. She had reached the court around 1015 hours.
Nobody was allowed in the court room except the CBI officials and lawyers for the dentist couple.
On April 27, the apex court had refused to stay the non-bailable warrant issued against Nupur by the Ghaziabad court.
Nupur surrendered today after a Supreme Court bench of justices A K Patnaik and J S Khehar had asked her to approach the trial judge for bail.
The bench had also turned down her plea for granting protection against any arrest after her surrender.