Affleck stepped in to stage the major fundraiser for consumer advocate Warren, who is fighting to reclaim Ted Kennedy's Massachusetts Senate seat for the Democrats, said The Hollywood Reporter.
Warren, a Harvard Law professor and former Obama administration aide, is locked in a tight and expensive race with former Tea Party favorite Scott Brown, whose campaign has been a major recipient of Wall Street donations.
The event at JJ Abrams' Bad Robot production studio in Santa Monica on Monday was billed as 'A Massachusetts Evening', and Affleck's co-hosts were Damon and Krasinski. Both Damon and Krasinski, however, were filming on location and couldn't attend the fundraiser.
Affleck, working on his own, made sure the event was packed. It drew about 150 Hollywood donors, along with more than 200 individual donations to the Warren senatorial effort.
Attendees included Affleck's wife Jennifer Garner, Reese Witherspoon, Zach Braff, Dana Delany, Tobey Maguire, Ed Zwick, Marshall Herskovitz, Alan Horn and Writers Guild president Chris Keyser.
Other contributors included Steven Spielberg, Rob Reiner, Jeffrey Katzenberg, Sally Field, Michael King, Harvey Weinstein and Alan Ladd Jr.