The poster shows Akshay riding a golden bike through a bright colourful sky in the background.
The film, based on Umesh Shukla's Gujarati play "Kanji Viruddh Kanji", will see Paresh Rawal play the character of Kanhaiya.
Akshay and Paresh were last seen together in 2008's "Phir Hera Pheri", a sequel to their hit film "Hera Pheri".
"Oh My God", co-produced by Akshay, is set to release on September 28.
