Tendulkar, whose last competitive game was a Test match between India and New Zealand in Bangalore earlier last month, will be keen on doing well as his performance will certainly have a bearing on Mumbai Indians' fortune in the tournament.
For the 39-year-old champion batsman, it will also be a chance to prove his detractors wrong after he was bowled thrice during the Test series against New Zealand while Harbhajan will like to use this opportunity to get requisite confidence and make a case for himself before the Test team selection.
Although Tendulkar's next international assignment is against England starting next month, a good performance against a local side on bouncy South African strip will give him a lot of confidence than what a Ranji Trophy game on a shirtfront can provide.
Along with a destructive opener in Richard Levi, the duo has the ability to destroy the Lions' attack that will be led by two left-arm bowlers of different nature. While Pakistan's Sohail Tanveer can trouble the batsman with clever variations, speed merchant Dirk Nannes can be a handful on lively tracks.
Harbhajan, who won man-of-the-match award against England in the recently concluded World T20 would like to show that the performance wasn't a mere flash in the pan.
The tournament will also be a test for Rohit Sharma who has consistently failed to deliver for India despite having the backing of his national team skipper Mahendra Singh Dhoni.
West Indian Dwayne Smith who didn't feature in West Indies' playing XI during the latter half of World T20 can also be considered for his all-round abilities.
Ambati Rayudu and Dinesh Karthik are two players who are expected to lend solidity to the middle-order while Kieron Pollard with his big-hitting prowess, steady seam-up stuff and electric fielding will be a crowd puller. More