President Bashar al-Assad has vowed to recapture the whole of Syria and keep "fighting terrorism" while also negotiating an end to the war, as international pressure mounts for a ceasefire.
His defiant stance, in an exclusive interview with AFP released today, doused hopes of an imminent halt to hostilities, which world powers are pushing to take effect within a week.
Assad said the main aim of a Russian-backed regime offensive in Aleppo province that has prompted tens of thousands of people to flee was to cut the rebels' supply route from Turkey.
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"It makes no sense for us to say that we will give up any part," he said in the interview conducted yesterday in Damascus.
Assad said it would be possible to "put an end to this problem in less than a year" if opposition supply routes from Turkey, Jordan and Iraq were severed.
But if not, he said, "the solution will take a long time and will incur a heavy price".
Assad said he saw a risk that Turkey and Saudi Arabia, key backers of the opposition, would intervene militarily in Syria.
World powers agreed today an ambitious plan to cease hostilities in Syria within a week, but doubts soon emerged over its viability, especially because it did not include IS or al-Qaeda's local branch.
US Secretary of State John Kerry said there were "no illusions" about the difficulty of implementing a nationwide "cessation of hostilities" as he announced the deal in Munich alongside Russian Foreign Minister Sergei Lavrov.
Lavrov underlined that "terrorist organisations" such as IS and Al-Qaeda-affiliated Al-Nusra Front "do not fall under the truce, and we and the US-led coalition will keep fighting these structures".
Russia says its more than four-month-old bombing campaign in Syria targets IS and other "terrorists", but critics accuse Moscow of focusing on mainstream rebels.
The Munich deal went further than expected, with Lavrov talking about "direct contacts between the Russian and US military" on the ground, where the powers back opposing sides in the five-year-old conflict.
The 17-nation International Syria Support Group also agreed that "sustained delivery" of humanitarian aid will begin "immediately".
But after Assad's forces this month nearly encircled Aleppo, Syria's second city, several nations put the onus on Moscow to implement the deal.