Likening themselves to a 'tennis pro and a crystal meth addict', Brand spoke openly about the couple's decision to call it a day on their 14-month marriage last December, reported Daily Mail.
"Sometimes it goes well, sometimes it don't, but if you sort of sense there's an incompatibility, then in any relationship regardless of the status of the individual, it kind of is best to go separate ways," said Brand.
The comedian spoke about why he believes people should date those with similar interests for the best chance of long-term compatibility.
"I think if you're someone who's really into mountain biking, it would be good to go out with someone else who's into mountain biking, and if you're really into Eastern mysticism, go out with someone else who into Eastern mysticism.
"I think if you're a devoted tennis professional and you get married to a crystal meth addict, you might have trouble... I've been in a lot of trouble," he said.