Human norovirus, a stomach bug that causes vomiting and diarrhoea, may also infect your canine companions, raising the possibility of dog-to-human transmission, a new study has claimed.
Norovirus is the leading cause of food-borne illness in the US, according to the Centres for Disease Control and Prevention (CDC).
The research showed that some dogs can mount an immune response to human norovirus, said first author Sarah Caddy, a veterinarian and PhD student at the University of Cambridge, and Imperial College, London, UK.
"This strongly suggests that these dogs have been infected with the virus. We also confirmed that that human norovirus can bind to the cells of the canine gut, which is the first step required for infection of cells," said Caddy.
Caddy and collaborators performed the research using non-infectious human norovirus particles, which consist solely of the virus' outer protein, called the capsid. The capsid is the part of the virus that binds to host cells.
By itself, it is non-infectious because it lacks genetic material.
Nonetheless, it is not clear just how much of a problem canine infection and transmission may represent for humans, said Caddy.
Despite dogs' apparent susceptibility, the investigators failed to find norovirus in canine stool samples, including those from dogs with diarrhoea. They found it in serum samples of only about one seventh of 325 dogs tested.
Additionally, it is not yet known whether human norovirus can cause clinical disease in dogs.
Assuming that dogs become infected with human norovirus as per this study, it also remains unknown whether they could shed the virus in quantities sufficient to infect humans - although clinical investigators have estimated that as few as 18 virus particles can cause human infection.
Moreover, it is yet to be determined whether dogs play a role in the epidemiology of some outbreaks of human norovirus. Some of the biggest outbreaks occur in places from which dogs are absent, such as on cruise ships and in hospitals.
Norovirus, which causes vomiting and diarrhoea, is extremely contagious among humans. It infects 19-21 million Americans annually - more than six per cent of the US population - according to the CDC. Those infections may result in as many as 71,000 hospitalisations, and 800 deaths.
"As a small animal veterinarian, I am often asked by dog owners if they might be able to pass infections onto their dogs, or if their dogs are contagious to them," said Caddy.
"There are plenty of anecdotal cases of dogs and humans in the same household, having simultaneous gastroenteritis, but very little rigorous scientific research is conducted in this area," said Caddy.
The research was published in the Journal of Clinical Microbiology.
