The CIA station chief in Germany left the country today after Berlin's shock decision last week to demand his expulsion, the US and German governments said.
"We are confirming that the individual who was asked to leave the country last week is no longer in Germany," a US embassy spokesman said.
A German foreign ministry spokesman also confirmed the news that the US spy chief had left.
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Germany last week ordered the CIA station chief out of the country amid the worst diplomatic row between the close NATO allies since the US-led invasion of Iraq in 2003, which Berlin vocally opposed.
Chancellor Angela Merkel's government made the dramatic announcement after two alleged German double agents working for the United States were unmasked.
Federal prosecutors are investigating a defence ministry employee and an agent for the BND foreign intelligence agency on suspicion of supplying secrets to Washington.
The cases stoked still seething anger in Berlin about revelations that the US National Security Agency conducted mass spying operations against targets including Merkel's mobile phone.
Merkel and US President Barack Obama spoke by telephone Tuesday for the first time since the expulsion order against the CIA chief.
A White House statement said little about the conversation, only that Obama and Merkel "exchanged views on US-German intelligence cooperation, and the President said he'd remain in close communication on ways to improve cooperation going forward."
Merkel's spokesman Steffen Seibert declined to reveal the content of the "confidential" conversation but stressed that Germany saw "deep differences of opinion on the issue of the activities of the US intelligence services".
In a interview with public television last Saturday, Merkel lamented the breakdown of trust between Germany and the United States and a return to the thinking of the "Cold War era where everyone is suspicious of everyone".
US Secretary of State John Kerry attempted to mend fences Sunday at talks with his German counterpart Frank-Walter Steinmeier in Vienna, insisting that the transatlantic allies remain "great friends".