Raza Jaffrey and Bonnie Somerville will not return to "Code Black" as series regulars.
The CBS medical drama is undergoing big changes ahead of its second season, according to The Hollywood Reporter.
That includes ditching Jaffrey as Dr Neal Hudson and Somerville as Dr Chris Lorenson.
In their absence, Boris Kodjoe - who appeared in four episodes of the first season as Will Campbell - will be promoted to regular.
"Code Black" creator Michael Seitzman has already taken to Twitter to respond to fan outcry over Jaffrey and Somerville's axings.
The 17-episode second season is also expected to add new regular characters to join Marcia Gay Harden as series lead Dr Leanne Rorish.
"Code Black" will return to CBS in the US and airs on W in the UK.
