Colombia left-back Franck Fabra limped out of the World Cup on Saturday in a significant blow to manager Jose Pekerman just 10 days before his side's first match.
The Boca Juniors defender will miss the tournament after suffering a knee ligament rupture in training, the Colombian football federation said.
Pekerman is due to announce the 27-year-old's replacement "in the next few hours", the federation said.
Colombia are in Group H with Poland, Senegal and Japan who they face in their opening fixture on June 19.
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