Real Madrid legend Alfredo di Stefano, one of the greatest footballers in history, died in a Spanish hospital today aged 88, the club said.
The Argentine-born former striker and honorary president was "the best player of all time", Real Madrid said.
Di Stefano had been taken to hospital after suffering a heart attack on Saturday.
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He had been taken in a serious condition to the Gregorio Maranon hospital which later said he was in a coma, had been sedated and was breathing with the help of a machine.
"Alfredo Di Stefano died today at 5:15 pm" (1515 GMT) at the Gregorio Maranon hospital in the Spanish capital, Real Madrid said in a statement on Monday.
"Real Madrid Football club's president Florentino Perez and the club's board of directors wish to express their deepest condolences and all their love and affection to his children, his family and friends," it added.
"Real Madrid extends its condolences to its fans around the world and to those who are feeling the emotion of losing the best player of all time."
On Saturday, newspaper El Pais said Di Stefano had been eating with his family when he felt ill and sat down in his wheelchair. By the time an ambulance arrived he was in cardiorespiratory arrest.
Di Stefano, who had previously been hospitalised for similar episodes, underwent emergency quadruple heart by-pass surgery after a heart attack in 2005.
He was one of Real Madrid's most celebrated players, having represented the club for 11 seasons between 1953 and 1964, winning five European Cups.