The 37-year-old actress was spotted enjoying some gentle exercise as she prepares for her new arrival, reported Daily Mail online.
Barrymore showed off her huge baby bump in a mauve T-shirt, comfortable white yoga pants, canvas shoes and red-rimmed, heart-shaped sunglasses.
She carried a red yoga mat, large grocery bag and a woven handbag slung over one shoulder, and used her one free hand to get into her car before heading home.
Barrymore tied the knot with Kopelman in an intimate wedding ceremony three months ago.