The 65-year-old music superstar has reportedly spent six months planning the bash, which will kick off next Wednesday at the couple's home in Beverly Hills, reported Daily Mail.
Guests will be flown in from all over the world and will be put up in the luxury Four Seasons Hotel in Beverly Hills, with party-goers on the list said to include Victoria and David Beckham, and model-actress Elizabeth Hurley.
On October 25, the day of Furnish's birthday, a dinner will be held for 200 people at the Belasco Theatre while on the next day the celebrations will continue at the Greystone Manor nightclub.
The festivities will conclude with a trip to Las Vegas on October 27, with guests being driven to Sin City to see John perform his Million Dollar Piano show at Caesars Palace.
Lady Gaga, Cher, Scissor Sisters and the Cirque du Soleil troupe are said to be among the artists booked to perform at the various events over the four-day stretch.