Federal health officials are investigating sometimes-deadly overdoses with common anti-diarrhea drugs, a bizarre manifestation of the nation's drug abuse problem.
The Food and Drug Administration warned doctors and patients Tuesday that the over-the-counter and prescription medications, including Imodium, can cause potentially deadly heart problems when taken in large doses.
The agency has received 31 reports of people hospitalized due to the heart problems, including 10 deaths over the last 39 years. The agency's database is not comprehensive and many drug overdoses are not reported to the government.
But national poison centers reported a 71 percent increase in calls involving the drugs between 2011 and 2014, according to a journal article published last month in the Annals of Emergency Medicine.
The paper's authors recommended restricting over-the-counter sales of anti-diarrhea drugs, similar to other easily abused medications like pseudoephedrine, the decongestant that can be processed into methamphetamine.
FDA regulators said in an online posting that they are monitoring the issue and considering next steps.
The primary ingredient in Imodium and similar drugs, loperamide, is intended to control diarrhea, with maximum-recommended doses ranging between 8 and 16 milligrams per day.
But abusers have reportedly tried to achieve heroin-like highs by taking massive doses, up to 300 milligrams at once, according to cases in the medical literature.
Reports of abuse are rising amid an epidemic of addiction and abuse involving opioids, a family of drugs that includes narcotics like heroin and legal prescriptions like morphine and oxycodone.
