The 42-year-old said she is yet to work out how much time she needs to spend with her children, reported Daily Mail.
"The question of balance has always been kind of a funny one to me because I don't think there is any balance. I feel like I've never done enough.
"I do think I'm pretty good at home, but trying to balance my energies outside the home? It's a challenge; there's so much more I want to do and can do," Thurman said.
The actress also confessed that when she was younger and became a mother she did not think that she could do anything else, as she was completely overwhelmed.
"When I was younger and became a mother, I didn't think I could do anything else; I was completely overwhelmed. I felt guilty and afraid about working, guilty and afraid about not working.
"It's very overwhelming for a younger person, which is why it's awesome to get to have another baby when you're grown up," she added.