Heavy combat fire rocked the outskirts of the strategic Ukrainian port city of Mariupol on Friday, just hours before talks open on a possible ceasefire.
A series of explosions were also heard in the main eastern rebel hub of Donetsk overnight, apparently coming from the city's airport, an AFP journalist said.
Mariupol has become the latest flashpoint in the near five-month conflict in eastern Ukraine as pro-Russian rebels wage a counter-offensive that has seen swathes of land seized from government forces in just a matter of days.
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AFP journalists reported heavy fire from the east of the city on Friday, with Ukrainian volunteer militias reporting attacks by insurgents on several checkpoints.
Ukrainian government forces had for weeks been besieging Donetsk, the biggest city in the largely Russian-speaking industrial east of the country in their battle to rout the rebels.
But the troops have now pulled back from positions around the city in the face of the insurgent advance.
The renewed fighting comes despite hopes that talks in the Belarussian capital Minsk later today on a peace plan unveiled by Russian President Vladimir Putin will lead to a ceasefire.
Russia denies it has any involvement in the conflict but NATO leaders are expected to announce a raft of fresh sanctions against Moscow on yesterday if no peace deal is agreed.