The accident occurred on Sunday night when the vehicle with nine passengers was on its way from Yingkiong to Pasighat in East Siang district.
The deceased were identified as Harjan Singh, teacher, his wife, Saraj Rawat, also teacher) both from Yingkiong Government Higher Secondary School, Ojing Modi (33 years) from Gette Village, Juho Taku (24 years) from Geku and Jotey Chettry, the driver of the vehicle.
The injured were admitted to District Hospital, Yingkiong, while one of the passenger who was critically injured has been evacuated to Dibrugarh for further treatment, officials said.