The victims were travelling in a tempo which collided head-on with a mini-truck near Piploda Phanta under Narwar Police Station, police said.
The passengers of the vehicle were on their way to a factory in Dewas from Ujjain. The injured were admitted in the Ujjain District Hospital in serious condition, police said.
The deceased were identified as Rajjak Khan (32), Dipesh Sharma (30), Tripti Padiyar (26) and Umabai (26), they added.