Francois Hollande arrived in Havana, the first French president to visit Cuba in more than a century, cementing Paris's lead in the EU rapprochement with the communist island.
Hollande is the first Western leader to visit Cuba since a surprise announcement in December by Havana and Washington that the former Cold War foes would move to normalize relations after half a century of bad blood.
Hollande arrived at Havana's Jose Marti International Airport at 22:50 (0250 GMT Monday) and was greeted by Cuba's Deputy Foreign Minister Rogelio Sierra, the latest leg of a whirlwind five-day tour of the Caribbean.
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No French leader has visited Cuba since the island nation gained independence in 1898.
"There are historic ties, deep ties, between the people of France and the people of Cuba," said Hollande, applauding Cuba's long-time commitment to independence.
The visit is aimed at boosting French and European Union interests in Cuba, which has undergone gradual economic and social reforms under Castro.
France is seeking to "be the first among European nations, and the first among Western nations, to be able to say to the Cubans that we will be at their side if they decide themselves to take needed steps toward opening up," Hollande told reporters before arriving in Havana.
The French president said the easing of a decades-long economic embargo by the United States will help Cuba's cash-strapped economy.
"Cuba wants to move on to a new phase, a new period, a new time for this island that was victim of an embargo," Hollande said on a stop in Guadeloupe, referring to the US sanctions in place since 1962.
The French leader said removing the embargo was key to opening Cuba up to the rest of the world, adding that despite the move toward thawing relations with Washington, economic barriers remain.
"There are still a lot of measures in place that block trade and business," Hollande said.
Several agreements will be signed during the trip, though the details of the deals were not made public. Hollande said the accords would focus on improved access to Latin American markets.