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Purified components of the humble ginger have properties that can help asthma patients breathe more easily, a new study has found.
Asthma is characterised by bronchoconstriction, a tightening of the bronchial tubes that carry air into and out of the lungs.
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Bronchodilating medications called beta-agonists are among the most common types of asthma medications and work by relaxing the airway smooth muscle (ASM) tissues.
Researchers from Columbia University in New York looked at whether specific components of ginger could help enhance the relaxing effects of bronchodilators.
"Asthma has become more prevalent in recent years, but despite an improved understanding of what causes asthma and how it develops, during the past 40 years few new treatment agents have been approved for targeting asthma symptoms," said lead author Elizabeth Townsend, post-doctoral research fellow in the Columbia University Department of Anesthesiology.
"In our study, we demonstrated that purified components of ginger can work synergistically with beta-agonists to relax ASM," said Townsend.
To conduct their study, the researchers took human ASM tissue samples and caused the samples to contract by exposing them to acetylcholine, a neurotransmitting compound that causes bronchoconstriction.
Next, the researchers mixed the beta-agonist isoproterenol with three separate components of ginger: 6-gingerol, 8-gingerol or 6-shogaol.
Contracted tissue samples were exposed to each of these three mixtures as well as unadulterated isoproterenol and the relaxation responses were recorded and compared.
Results showed that tissues treated with the combination of purified ginger components and isoproterenol exhibited significantly greater relaxation than those treated only with isoproterenol; of the three ginger components, 6-shogaol appeared most effective in increasing the relaxing effects of the beta-agonist.
Researchers wanted to determine if the ginger components might work by affecting an enzyme called phosphodiesterase4D (PDE4D). Using a technique called fluorescent polarisation, they found that all three components significantly inhibited PDE4D.
Next, the study looked at F-actin filaments, a protein structure which previous studies have shown plays a role in the constriction of ASM, and found that 6-shogaol was effective in speedily dissolving these filaments.
"Taken together, these data show that ginger constituents 6-gingerol, 8-gingerol and 6-shogaol act synergistically with the beta-agonist in relaxing ASM, indicating that these compounds may provide additional relief of asthma symptoms when used in combination with beta-agonists," Townsend noted.
The results of the study will be presented at the American Thoracic Society 2013 International Conference.
