For the first time, SpaceX today launched both a rocket and a cargo ship that have flown before, a step forward in the company's goal to lower the cost of spaceflight.
After the launch the California-based company headed by Internet tycoon Elon Musk landed its rocket booster upright on solid ground at Cape Canaveral, Florida.
SpaceX has now managed to return 20 of its rocket boosters after launch, whether on land or on a floating ocean platform, as part of its effort to re-use instead of jettison costly rocket components.
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The recycled Dragon spacecraft and Falcon 9 rocket blasted off at 10:36 am (local time).
Three minutes later, the booster and second stage of the rocket separated, as SpaceX's webcast showed the two components making an arc away from each other in the sky.
Then, the second stage continued to propel the Dragon toward the International Space Station, while the tall portion of the rocket powered its engines to guide it back to Landing Zone 1 at Cape Canaveral Air Force Station.
It was the 14th recovery of a booster for SpaceX this year alone.
"This is the beginning of rapid and reliability reusability," said SpaceX Dragon mission manager Jessica Jensen, at a press briefing Monday.
The launch was initially set for last Friday but was delayed, as SpaceX said it was "taking additional time for the team to conduct full inspections and cleanings due to the detection of particles in the second stage fuel system."
The Falcon rocket booster previously propelled a space station resupply mission in June, called CRS-11.
The Dragon capsule was flown to the ISS in 2015.
Today also marked the fourth time SpaceX is re-flying a used booster for one if its clients.
However, it was the first such effort for NASA, SpaceX's most important customer.
NASA's ISS program manager Kirk Shireman said rocket experts from around the agency had reviewed safety for the mission.
"The net result is about equivalent risk," he told reporters Monday.
The unmanned spaceship is packed with 4,800 pounds (2,200 kilograms) of food, supplies and experiments -- including one to study thyroid cancer and another to grow barley in space.
The mission is SpaceX's 13th of 20 under a $1.6 billion contract with NASA.
The Dragon is scheduled to arrive at the ISS on Sunday.
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