The Immigration and Customs Enforcement (ICE) said the 37 men and three women who were arrested include convicted criminal aliens, immigration fugitives and immigration violators.
They were arrested during a three-day operation in the greater Indianapolis area.
Thirteen have been previously ordered to leave the country but did not go.
Thirty-three of those arrested are from Mexico. ICE says others are from El Salvador, Cuba, Guatemala, Honduras, India and Peru.
The ICE says 25 have prior convictions for crimes including assault, domestic battery, drunken driving and drug charges. PTI
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