In the post game conference Anand candidly admitted he missed a move.
"I should have at least thought about it," he said.
Once the centre was opened, Caruana had no problems and subsequent exchanges led to a drawn opposite coloured Bishops endgame where the peace was signed after 40 moves. Naiditsch pushed hard for a victory and his efforts were rewarded when Adams cracked under pressure.
The Nimzo Indian by the English met with some classical response and it was a tense affair after Naiditsch gave up his queen side pawns for an ambitious attack.
Adams decided to part with a rook for knight but his position remained difficult to defend. After nearly seven hours, the German romped home.
Fridman and Meier played out a draw through repetition of moves from an irregular queen pawn game. The shortest game of the day lasted just 26 moves.
Results round 2: V Anand (Ind, 1) drew with Fabiano Caruana (Ita, 1.5); Arkadij Naiditsch (Ger, 1.5) beat Michael Adams (Eng, 0.5); Daniel Fridman (Ger, 1) drew with Georg Meier (Ger, 0.5).
The moves: V Anand � Fabiano Caruana
1. E4 e5 2. Nf3 Nc6 3. Bb5 a6 4. Ba4 Nf6 5. O-O Be7 6. Re1 b5 7. Bb3 d6 8. C3 O-O 9. H3 Re8 10. D4 Bb7 11. Nbd2 Bf8 12. D5 Nb8 13. Nf1 Nbd7 14. N3h2 Nc5 15. Bc2 c6 16. B4 Ncd7 17. Dxc6 Bxc6 18. Bg5 h6 19. Bxf6 Nxf6 20. Ng4 a5 21. Nxf6+ Qxf6 22. Ne3 axb4 23. Cxb4 d5 24. Exd5 Bd7 25. Qb1 g6 26. D6 Rad8 27. A4 Bxd6 28. Axb5 e4 29. Bxe4 Qf4 30. Nf1 Bxb5 31. G3 Qf6 32. Bg2 Rxe1 33. Qxe1 Bxf1 34. Qxf1 Bxb4 35. Ra8 Rxa8 36. Bxa8 Bd6 37. Kg2 Kg7 38. Bf3 Bf8 39. Qe2 Qe7 40. Qxe7 game drawn.