The HRT team announced that the Spaniard, who had his first outing with the team on home soil at Barcelona last month, will be at the cockpit in place of Karthikeyan for free practice one.
He and Pedro de la Rosa will be at the HRT wheels for the first 90 minutes of practice at the iconic circuit with Karthikeyan taking over for the remainder of the weekend.
Speaking about his opportunity, Clos said, "I'm very happy to step into the F112 once again in Silverstone, a place where I've got good memories since I've made the podium every time I've been in GP2. After Barcelona I've really been looking forward to this new opportunity.
"The work we're carrying out with the team is positive and I think that I can make a good contribution. I will be able to run in better conditions than in Barcelona because the car was new back then and I had to carry out various aero tests. Now I've got a new opportunity, not to prove anything but to work with the team and evolve as much as we can."