Johansson, 27, was slated to star in the film, "A Song Can Save Your Life" opposite "The Avengers" co-star Mark Ruffalo, but has pulled out of the project, reported Contactmusic.
Reports suggest Ruffalo too may have departed the film, which is about a struggling singer, but "True Grit" star Hailee Steinfeld is still a member of the cast.
In the film Knightley's singer character arrives in New York looking for love and meets a washed-up record producer.