/ -- Manipal Hospitals Jaipur performed a rare and unique ABO incompatible kidney transplant to give new lease of lives to 52-year-old Mr. Aditya (name changed), 18-year-old Mr. Ravi Soni and 39-year-old Mrs. Rajbala.
Although worldwide popularity of ABO incompatible renal transplant is increasing, however developing nations have their own limitations such as high cost, risk of antibody-mediated rejection and increased incidence for post-transplant infections. These transplants were complicated as there was a blood group mismatch among the recipients and donors. Despite all the hurdles, the kidney transplant team of Manipal Hospitals Jaipur successfully performed three ABO incompatible kidney transplantations. All patients are living an active healthy life with normal kidney function.
Mrs. Asha Devi (name changed) 51-year-old became the donor for her 52-year-old husband Mr. Aditya (name changed). In this case the donor's blood group was AB+ and recipient's blood group was B+. In the second case Mrs. Abhilasha Soni, 38-year mother became the donor to her 18-year-old son. The donor's blood group was B+ and her son's (recipient) blood group was O+. Lastly, 39-year-old Mrs. Rajbala was donated kidney by her 57-year-old paternal aunt Mrs. Subesar in a heartwarming gesture. The blood group of the recipient was O+ and while the donor's blood group was B+.
All the patients were suffering from end-stage kidney issue and transplant was the last option. Since their health was deteriorating and they could not wait for cadaver transplant, their family members offered to become the donors to save their lives.
Sharing details on this rare kidney transplant, Dr. Jitendra Goswami & Dr. Alok Pandey, Nephrologist, Manipal Hospitals Jaipur said, "Kidney transplantation is the best form of Renal Replacement Therapy (RRT) for End-stage Renal Disease (ESRD) patients. Only 10% of ESRD patients receive any form of RRT in India and only 2% undergo renal transplantation. Due to mismatch blood group approximately 35%, willing donors are rejected. This barrier can be removed with ABO incompatible (blood group mismatch) kidney transplantation. With an ABO incompatible kidney transplant, you receive medical treatment before and after your kidney transplant to lower antibody levels in your blood and reduce the risk of antibodies rejecting the donor's kidney."
"For removal of antibodies, we give special injection (Rituximab) and we do Cascade Plasma Exchange (Double Filtration Plasma Exchange), a process that filters the blood and removes harmful antibodies," said Dr. Ravi C Dara, Immunologist at Manipal Hospitals Jaipur.
"Long Term studies have shown that outcome of ABO incompatible renal transplant is almost similar to the ABO compatible transplant and risk of infection is also comparable. So, ABO incompatible renal transplant is a boon for CKD Patient especially in our country in view of increasing no. of ESRD potential & limited number of Kidney donors," said Dr. D R Dhawan & Dr. Jyoti Bansal, Urologist at Manipal Hospitals Jaipur.
Speaking on the occasion, Mr. G. Karthihaivelan, Hospital Director, Manipal Hospitals Jaipur said, "Manipal Hospitals Jaipur is always at the fore when it comes to using innovative technology in healthcare. This is a great milestone and for the same I congratulate the nephrology department as the team of doctors displayed utmost commitment and dedication. With high standard of healthcare services and expert pool of doctors, we have touched many lives since the inception of Manipal Hospital Jaipur. At present, our Hospital has the finest state of the art infrastructure with advanced cutting edge technology in Rajasthan. This drives the hospital to deliver path-breaking care for patients on a day-to-day basis. We constantly endeavour to provide world class medical treatments to our patrons."
About Manipal Hospitals:
As a pioneer in healthcare, Manipal Hospitals is among the largest hospital network in India serving over 2 million patients annually. Its focus is to develop an affordable tertiary care multispecialty healthcare framework through its entire multispecialty delivery spectrum and further extend it to homecare. With its flagship quaternary care facility located in Bangalore, India, 7 tertiary care, 5 secondary care and 2 primary care clinics spread across India and abroad, today Manipal Hospitals successfully operates and manages 5,900 beds across 15 hospitals. Manipal Hospitals provides comprehensive curative and preventive care for a multitude of patients from across the globe. Manipal Hospitals has one-day care clinic in Lagos, Nigeria. Manipal Hospitals is first in India to be awarded accreditation by the AAHRPP for ethical standards in clinical research activities. It is also NABL, NABH and ISO certified. Manipal Hospitals is also the most respected hospital company in India and the most patient recommended hospital in India by consumer survey.
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