Cameron White is leading the visiting side after regular captain Kumar Sangakkara opted out of the playing XI.
The Chargers included Dale Steyn, Dan Christian and V Pratap Singh in their team and left out Sangakkara, Manpreet Gony and Juan Theron.
MI brought back opener Richard Levi, James Franklin pacer Munaf Patel while leaving out injured allrounder Kieron Pollard, Aiden Blizzard and Rahul Shukla.
The teams (from):
Mumbai Indians: Harbhajan Singh (Capt.), Sachin Tendulkar, James Franklin, Richard Levi, Ambati Rayudu, Dinesh Kartik, Lasith Malinga, Munaf Patel, Robin Peterson, Rohit Sharma, Rudra Pratap Singh.
Deccan Chargers: Cameron White (capt.), Parthiv Patel, Shikhar Dhawan, Bharat Chipli, Jean Paul Duminy, Dan Christian, Ashish Reddy, Amit Mishra, Ishank Jaggi, Dale Steyn, Veer Pratap Singh. PTI SSR AH
