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Molecular machine could make manufacturing more efficient

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Press Trust of India London

The artificial molecular machine developed by Professor David Leigh and his team at the University of Manchester could be seen as an industrial revolution on a minute scale.

"The development of this machine which uses molecules to make molecules in a synthetic process is similar to the robotic assembly line in car plants. Such machines could ultimately lead to the process of making molecules becoming much more efficient and cost effective," Leigh said in a statement.

This will benefit all sorts of manufacturing areas as many man-made products begin at a molecular level. For example, we're currently modifying our machine to make drugs such as penicillin, he said.

 

The machine is just a few nanometres long (a few millionths of a millimetre) and can only be seen using special instruments. Its creation was inspired by natural complex molecular factories where information from DNA is used to programme the linking of molecular building blocks in the correct order.

The most extraordinary of these factories is the ribosome, a massive molecular machine found in all living cells.

Professor Leigh's machine is based on the ribosome. It features a functionalised nanometre-sized ring that moves along a molecular track, picking up building blocks located on the path and connecting them together in a specific order to synthesise the desired new molecule.

Professor Leigh says the current prototype is still far from being as efficient as the ribosome, "The ribosome can put together 20 building blocks a second until up to 150 are linked. So far we have only used our machine to link together 4 blocks and it takes 12 hours to connect each block."

But you can massively parallel the assembly process, We are already using a million million million (1018) of these machines working in parallel in the laboratory to build molecules, he said.

"The next step is to start using the machine to make sophisticated molecules with more building blocks. The potential is for it to be able to make molecules that have never been seen before.

They're not made in nature and can't be made synthetically because of the processes currently used. This is a very exciting possibility for the future, Leigh said.

  

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First Published: Sep 09 2010 | 2:10 PM IST

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