The incident occurred at 6:20 AM near Chakarbanda forests in Barha village of the district when the CRPF vehicle was going for an operational duty.
While two personnel inside the vehicle were killed on the spot, eight others were injured, officials said.
Three troopers were seriously injured in the blast. An IAF helicopter from Ranchi has been rushed to evacuate the causalities.
The troopers belong to 159 battalion of the force deployed in the state for anti-Naxal operation tasks.
It is suspected that Maoists used a huge quantity of explosives to detonate the Improvised Explosive Device (IED).