Scientists have identified a particular type of neurons that may be activated to influence a person to stop drinking alcohol.
Previous research has shown that alcohol consumption alters the physical structure and function of neurons, called medium spiny neurons, in the dorsomedial striatum.
Researchers from Texas A&M Health Science Center College of Medicine earlier found that activation of one type of neuron, called D1, determines whether one drink leads to two. Now, they have discovered the ones that tell us to stop.
These neurons can be thought of like a tree, with many branches, and many small protrusions, or spines, coming off of them.
Each neuron has one of two types of dopamine receptors - D1 or D2 - and can be thought of as either D1 or D2 neurons. When D2 neurons are activated, they discourage action.
"At least from the addiction point of view, D2 neurons are
good," said Jun Wang, assistant professor at the Texas A&M College of Medicine.
"When they are activated, they inhibit drinking behavior, and therefore activating them is important for preventing problem drinking behavior," Wang said.
The trouble is, even in individuals without alcoholism, D2
neurons tend to become deactivated when we drink too much. This deactivation means there is nothing telling us to stop drinking, so we drink more, in a self-perpetuating cycle.
The researchers found that in animal models, repeated cycles of excessive alcohol intake, followed by abstaining from alcohol, actually changed the strength of these neuronal connections, making D2 signals less powerful - which results in essentially training the individual to seek alcohol.
"Think of the binge drinking behavior of so many young adults," Wang said.
"Essentially they are probably doing the same thing that we've shown leads to inhibition of these so-called 'good' neurons and contributes to greater alcohol consumption," he said.
These findings provide insight into another mechanism underlying the complicated disease we call alcoholism.
"Our current and previous research are essentially two sides of the same coin," Wang said.
"D1 and D2 medium spiny neurons have essentially opposing roles in alcohol consumption," he said.
By manipulating the activity of these neurons, the researchers were actually able to change the alcohol-drinking behavior of the animal models who had been "trained" to seek alcohol.
By activating D2 neurons, they were able to decrease alcohol consumption, and the more the D2 neurons were activated, the greater the effect is likely to be.
Although Wang cautions that we are still a long way from testing this in humans, in theory, if we could someday use drugs or electrical stimulation to activate D2 neurons, we may be able to prevent alcoholics from wanting another drink.
The study was published in the journal Biological Psychiatry.
