The benchmark Nifty snapped its eight-day rise, slipped by 29 points to end at 10,370.25, amid profit booking mainly in PSU banks, energy, infra, realty, pharma and IT counters.
Bearish global cues and a caution ahead of September- quarter GDP data too made investors watchful.
Overseas, European markets were trading steady to higher in early trade as concerns over political tensions in German subsided and market sentiment improved.
Asian stocks finished broadly lower amid uncertainty over the US tax bill.
The NSE Nifty opened lower at 10,387.90 and moved in a range of 10,409.55 and 10,355.20 before closing down by 29.30 points, or 0.28 per cent, at 10,370.25.
It saw an intra-day movement of 54.35 points.
At the broader markets, the Nifty small cap rose by 0.57 per cent and mid-cap indices moved up 0.07 per cent.
Sector-wise, media surged by 0.17 per cent.
While, PSU fell by 1.10 per cent followed by energy 0.94 per cent, infra 0.83 per cent, pharma 0.54 per cent, realty 0.44 per cent, IT 0.39 per cent and bank 0.18 per cent.
Major index losers were Infratel, Auro Pharma, NTPC, Sun Pharma, ONGC, Infosys, Tata Motors and Bharti Airtel.
Gainers included Zeel, Indiabulls Housing Finance, Maruti, Asian Paint, IndusInd Bank, UPL, HDFC, Coal India and Hindustan Unilever.
The market breadth, indicating the overall health, was in favour of losers. On the NSE, 857 shares advanced and 895 declined, while 75 remained unchanged.
Total securities that hit their price bands were 177.
Turnover in the cash segment rose to Rs 32,659.59 crore, from Rs 27,083.79 crore as on Monday.
A total of 19,665.77 lakh shares changed hands in 1,13,50,754 trades. The market capitalisation of listed firms on the NSE stood at Rs 1,45,13,953.15 crore.
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