The underwear is designed to deliver a mild 10 second shock to buttocks every 10 minutes for 12 hours a day by using two electro-pads on each buttock.
The study of 37 patients showed that none of them developed a sore during the month long trial.
Sores form when people are stuck in one position for too long, which compresses the skin and cuts off the blood supply.
Canadian academics said that in a short trial on 37 people, the mild current mimicked fidgeting and prevented the sores forming, the Florida News journal reported.
Doctors at the University of Calgary found that patients who were unable to move because of a spinal cord injury were zapped with 10 seconds of stimulation every 10 minutes for 12 hours a day.
"Pressure ulcers can be terribly debilitating," Robyn Rogers, a research nurse at the university, said.
"Their incidence has not changed since the 1940s, indicating that the current methods of prevention simply are not working.
"Our hope is that this innovative, clinically friendly system will eventually make a difference in the lives of millions of people," Rogers said.
Researchers said the pants were popular with nurses and patients, however, much larger studies would be needed to test how effective the underwear was at preventing bedsores.
Pressure sores are a common problem in hospitals around the world as patients are often too ill to get out of bed.
Older people are at heightened risk because of poor circulation.
The findings were presented at the Neuroscience 2012 conference.
