After battling it out in an annual boat race for over 150 years, rivals Oxford and Cambridge will now for the first time also compete on a racecourse in what could become an annual contest between the two prestigious institutions.
Their teams, which will be selected in the coming weeks, will don the institutions' distinctive sporting colours to race on horseback at Newmarket in front of a crowd of 10,000 people.
The race will take place in October over eight furlongs on the course's Rowley Mile, with five riders competing from each university.
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The initiative was thought up by Harry Beckett, a student at Oxford, and put together by Great British Racing, the promotional body for the sport.
The horseracing industry said the event had "captured the imaginations" of both universities, with the number of students applying to compete in the race exceeding the number of places available.
Seven riders from each university are now being trained at the British Racing School in Newmarket, Suffolk, and Oaksey House, a facility in Berkshire.
The final five riders for each of the institutions will be chosen in early October.
Great British Racing said that while both Oxford and Cambridge have active equestrian clubs this will be the first time they have faced each other on a racecourse.
The race will form part of the Dubai Future Champions Day at Newmarket on October 17, featuring the sport's youngest horses.
The riders from Cambridge will be wearing silks in the light blue worn by their rowing team, while those from Oxford will be wearing the dark blue used by their boat club.
Beckett said: "I've spent two years trying to get this race off the ground so I'm delighted to see it come to fruition. Fingers-crossed it will become an annual event, enabling riders to qualify for a Blue in future years."
A spokesman for Great British Racing said: "There is already quite a keen rivalry. There is every intention to do it every year.