Researchers from the University of Adelaide found reduced 'plasticity' in the brains of teenagers who were born preterm (at or before 37 weeks gestation).
"Plasticity in the brain is vital for learning and memory throughout life," researcher Dr Julia Pitcher said.
"It enables the brain to reorganise itself, responding to changes in environment, behaviour and stimuli by modifying the number and strength of connections between neurons and different brain areas. Plasticity is also important for recovery from brain damage," Pitcher said.
"We know from past research that preterm-born children often experience motor, cognitive and learning difficulties," Pitcher added.
"The growth of the brain is rapid between 20 and 37 weeks gestation, and being born even mildly preterm appears to subtly but significantly alter brain microstructure, neural connectivity and neurochemistry," she said in a statement.
"However, the mechanisms that link this altered brain physiology with behavioural outcomes - such as memory and learning problems - have remained unknown," she said.
The researchers compared preterm adolescents with those born at term, and also with term-born adults. They used a non-invasive magnetic brain stimulation technique, inducing responses from the brain to obtain a measure of its plasticity.
Levels of cortisol, normally produced in response to stress, were also measured to better understand the chemical and hormonal differences between the groups.
"Teenagers born preterm clearly showed reduced neuroplasticity in response to brain stimulation," Pitcher said.
"Surprisingly, even very modest preterm birth was associated with a reduced brain response. On the other hand, term-born teenagers were highly 'plastic' compared with adults and the preterm teens," she said.
"Preterm teens also had low levels of cortisol in their saliva, which was highly predictive of this reduced brain responsiveness. People often associate increased cortisol with stress, but cortisol fluctuates up and down normally over each 24-hour period and this plays a critical role in learning, the consolidation of new knowledge into memory and the later retrieval of those memories," Pitcher said.
The study was published in the Journal of Neuroscience.
