Priyanka Chopra, Taylor Swift, Josh Groban and Ryan Seacrest are among the celebrities who have condemned the attack in New York's Lower Manhattan.
At least eight people were killed and 11 other injured in the area after a gunman in a truck plowed through a busy bike path, an incident the US termed as an "act of terrorism".
Priyanka praising the city, her new home, for its grit on Twitter and shared that the attack took place "five blocks" away from where she lives.
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"This happened five blocks from my home. As I drive back home from work, dreary sirens remind me that this is the state of the world," the "Quantico" star tweeted.
Taylor Swift shared a photo of a sunset on her Instagram Story and captioned it, "I love you New York" and a broken heart emoji.
Josh Groban narrated the incident in a series of tweets, saying that he heard gun shots and ran with downtown with his dog.
"I hope everyone's ok. Was half a block from me, didn't see it but heard 8-10 quick rounds fired off. Be safe with your kids out there.
"I'm shaking. That's the corner I was supposed to have my coffee but my dog pulled me into the park half a block away 10 min before shooting.
"Devastated for the victims and their families tonight and inspired by the spirit of this city. Sirens and trick or treaters everywhere," he tweeted.
Zoe Saldana wrote, "My heart is broken. Sending prayers to all the victims who's lives were taken today in NYC."
Host Ryan Seacrest condemned the attack, calling it a "cowardly act".
"My heart goes out to those who have lost loved ones today in NYC," he wrote.
"This is a terrible day. Families will be mourning their loved ones tonight. This is an action is the worst of mankind," wrote Patricia Arquette.
Comedian Billy Eichner retweeted a news article and wrote, "That's my high school in the picture. This is sad and horrifying. Sending love to everyone there."
Singer Sam Smith tweeted, "New York. My heart is with you always and forever. Devastating news. My soul and heart is with the victims and there loved ones. Horrific."
The incident that took place in Manhattan, the most densely populated of New York City's 5 boroughs, has sent shocking waves across the country.
The suspect, a 29-year-old man, was shot in the stomach before being taken into custody.
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