"These remarks not only lack reality but are derogatory and defamatory for the youth of Punjab," Mittal told reporters here.
The Health minister said the Congress general secretary must tender an unconditional apology and clarify what prompted him to issue such an "irresponsible statement".
On Thursday, Gandhi told a rally in Chandigarh "what is happening to human resources in Punjab. Seven out of 10 youths have the problem of drugs."