The 36-year-old actor will star alongside Timothy Spall and Charles Dance in the Robert Connolly-directed film about a husband whose wife goes missing in unusual circumstances, reported Contactmusic.
Michael Hirst, Francesca Brill and Susie Brooks-Smith have written the film and it is due to shoot in 2013 ahead of a release the following year.
Australian actor Worthington was last seen in "Wrath of the Titans" in which he played Perseus.
He has a number of projects coming up including "Drift", "Thunder Run" and the "Avatar" sequel.
