The second seeded Indo-American pair erased the first set deficit to down the fourth seeded rivals 4-6 6-4 10-7 in the summit showdown of the USD 1,000,000 event.
It was Sania's first doubles title of the season while 15th of her career.
Sania and Mattek earned 470 ranking points each and shared USD 51,022 as prize money.
