The 30-share index fell 115.50 points, or 0.59 per cent, to 19,338.42.
Similarly, the wide-based National Stock Exchange Nifty moved down by 38.80 points, or 0.66 per cent, to 5,877.60.
All sectoral indices led by realty and metal were trading in the negative zone with losses up to 1.06 per cent.
Brokers said sustained selling by funds amid a weak trend in the Asian region largely in line with overnight losses on the US market as uncertainty grows over fiscal cliff mainly influenced the trading sentiment.
Meanwhile in Asia, Japan's Nikkei index fell by 0.71 per cent, while Hong Kong's Hang Seng index declined by 0.42 per cent in early trade today.
The US Dow Jones Industrial Average ended 0.45 per cent lower in yesterday's trade.
