The 30-share index, which had lost 46.30 points in the previous session on Tuesday, fell by 204.08 points, or 1.10 per cent, to 18,291.93 with stocks of metals, capital goods, auto and realty sectors leading the fall.
The markets remained closed yesterday for "Ganesh Chaturthi".
Similarly, the wide-based National Stock Exchange index Nifty dropped by 65.15 points, or 1.16 per cent, to 5,534.90.
Brokers said trading sentiment turned weak following political crisis after Trinamool Congress, the second biggest constituent of the ruling UPA, decided to withdraw its support on the issue of petroleum price hike, FDI in retail and corruption, triggering selling by participants.
A weakening trend in the Asian region ahead of manufacturing data from China too dampened the sentiment, they said.
In Asia, Hong Kong's Hang Seng index fell by 0.43 per cent, while Japan's Nikkei Index shed 0.70 per cent in the morning trade today.
The US Dow Jones Industrial Average ended 0.10 per cent higher in yesterday's trade.
