The 30-share index, which had gained 40.73 points in the previous session, fell by 68.24 points, or 0.40 per cent, to 16,849.84, with stocks of metals, realty and oil gas leading the fall.
Similarly, the wide-based National Stock Exchange index Nifty declined by 17.40 points, or 0.34 per cent, to 5,110.80.
Brokers said besides profit-booking by speculators after yesterday's gains, a weak trend on other Asian markets following overnight losses at the US markets amid euro-zone debt concerns and soft US corporate earnings mainly influenced the trading sentiment here.
They said a cautious approach adopted by participants in the absence of any positive trigger and tomorrow's monthly expiry in the derivatives segment too dampened the sentiment.
In the Asian region, Hong Kong's Hang Seng index fell by 0.97 per cent, while Japan's Nikkei Index shed 0.91 per cent in the morning trade today. The US Dow Jones Industrial Average ended 0.82 per cent lower in yesterday's trade.
