The 30-share barometer, which had lost almost 493 points in the previous three sessions, fell further by 73.99 points, or 0.45 per cent, to 16,346.06 in early trade today.
All sectoral indices, led by metal and oil and gas, were trading in the negative zone with losses of up to 0.71 per cent.
Similarly, the wide-based National Stock Exchange Nifty index declined by 25.55 points, or 0.51 per cent, to 4,940.15.
Brokers said expectations of lower industrial output data for March to be released later today, mainly triggered selling by funds and retail investors.
Meanwhile, in the Asia region, Hong Kong's Hang Seng index was down 1.08 per cent, while Japan's Nikkei Index up 0.45 per cent in morning trade.
The US Dow Jones Industrial Average ended 0.16 per cent higher in yesterday's trade.
