The 30-share Sensex, which lost almost 284 points in the previous four sessions, fell further by 167.54 points, or 0.90 per cent, to 18,451.33.
Similarly, the wide-based National Stock Exchange Nifty declined by 48.50 points, or 0.86 per cent, to 5,618.45.
Brokers said sustained selling by funds amid a weak trend at Asian bourses following overnight losses at the US market as investors worry about the fiscal cliff, mainly dampened the trading sentiment here.
However, marginal decline in inflation numbers to 7.45 per cent in October capped the losses, they added.
Meanwhile, in Asia, Hong Kong's Hang Seng index fell by 1.18 per cent, while Japan's Nikkei was up 0.96 per cent in opening trade.
The US Dow Jones Industrial Average tumbled 1.45 per cent to its lowest close since June 26 lower in yesterday's trade.
