A simple new test can predict whether men with zero sperm counts are capable of fathering children through in-vitro fertilisation (IVF), scientists say.
Current methods rely on surgery to find out if a man has viable sperm that can be retrieved for fertility treatment.
The new non-invasive test has identified two bio-markers in sperm, which can be used to predict whether sperm retrieval will be successful, 'BBC News' reported.
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Fertility treatment can sometimes help men who produce no sperm to father a biological child if they have normal sperm that can be extracted surgically.
Others are unable to father a child naturally and need to use donor sperm.
Using current technology, the only way to find out if a man has viable sperm is to carry out surgery to look for sperm in the testes.
The study suggests two bio-markers can identify who will benefit from surgery, the report said.
The holy grail of the new research was to find a way to help men avoid unnecessary testicular biopsies, said Dr Keith Jarvi of the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital in Toronto, Canada.
The study was published in the journal Science Translational Medicine.