Four civilians, including a toddler, were killed and 21 injured in Israeli missile strikes near Damascus late Sunday, Syria's state news agency SANA reported.
An AFP correspondent in Damascus reported hearing loud explosions during the night.
The Syrian news agency said the missiles struck near Damascus and in Homs province.
"Our air defences confronted enemy missiles launched by Israeli warplanes (...) towards some of our positions in Homs and in the vicinity of Damascus," SANA said, quoting a Syrian military source.
No details were given on the positions.
An Israeli military spokeswoman declined to comment on the report.
The Syrian Observatory for Human Rights, a Britain-based monitor, said the strikes hit several Iranian positions near Damascus and targeted a research centre and a military airport west of the city of Homs where the Hezbollah Shiite movement and Iranians are deployed.
Rami Abdel Rahman, the observatory chief, said the strikes injured some of these forces.
Israel has carried out hundreds of air strikes in Syria since the beginning of the conflict in 2011, targeting forces loyal to President Bashar al-Assad and the regime's allies Iran and Hezbollah.
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