The 67-year-old actress, who won an Oscar for portraying the Queen in the 2006 film of the same name, will play Her Majesty from the age of 25 to the present day in 'The Audience', reported Daily Mail.
The play will look at the Queen's weekly meetings with prime ministers during that period, from Winston Churchill to David Cameron.
In studying for the role Mirren has said the Queen has shown incredible consistency in everything she does over the years, in her clothes, hairstyle and professional attitude.
But she has noticed one slight change in that time, in the accent the Queen has used.
"Her voice has changed, and I can use that... She had a terribly posh voice when she was young. But now even the Queen, while she isn't quite dropping the ends of her lines - though her grandsons do - there's a tiny bit of estuary creeping in there.
"I can use all that to signify the age range and we'll come up with other things," said Mirren.
