The drone fired two missiles at the compound in Mirali area of North Waziristan tribal agency, officials were quoted as saying by the media.
The attack left at least three militants dead and several others injured, they said.
Earlier in the day, a US drone crashed in an uninhabited area near Wana, the main town of South Waziristan tribal agency, local residents and officials said.
There were no reports of damage on the ground due to the crash.
Officials of the local political administration said they were investigating the incident.
