Scientists have for the first time found a biological basis to back the belief of some people who maintain that eating tomatoes may cause their gout to flare up.
Gout is a painful and debilitating form of arthritis that affects approximately three times more men than women.
Once a person has gout, eating certain foods can cause their gout to flare up in a painful attack.
Researchers from the Department of Biochemistry at the University of Otago in New Zealand noticed that a large number of gout sufferers believe tomatoes to be one of these gout trigger foods.
The researchers surveyed 2,051 New Zealanders with clinically verified gout. Of these people 71 per cent reported having one or more food triggers. Tomatoes were listed as a trigger in 20 per cent of these cases.
Tanya Flynn, a PhD student at University of Otago, and one of the study authors, said that tomatoes were found to be the fourth most commonly mentioned trigger, after seafood, alcohol and red meat.
"We thought it important to find a biological reason for this to add weight to what gout patients are already saying," Flynn said.
After determining tomatoes are a commonly cited trigger food, the authors pooled and analysed data from 12,720 male and female members of three long-running US health studies.
This data showed that tomato consumption is linked to higher levels of uric acid in the blood, which is the major underlying cause of gout.
Flynn said that while their research is not geared to prove that tomatoes trigger gout attacks, it does suggest that this food can alter uric acid levels to a degree comparable to other commonly accepted gout trigger foods.
"We found that the positive association between eating tomato and uric acid levels was on a par with that of consuming seafood, red meat, alcohol or sugar-sweetened drinks," she said.
Flynn emphasised that the most important thing that people with gout can do to prevent attacks is take a drug - such as Allopurinol - that is very effective at reducing uric acid levels.
"Avoiding tomatoes may be helpful for people who have experienced a gout attack after eating them, but with proper treatment this doesn't have to be a long-term avoidance," she said.
"Further intervention studies are needed to determine whether tomatoes should be added to the list of traditional dietary triggers of gout flares, but this research is the first step in supporting this idea," said Flynn.
The study was published in the journal BMC Musculoskeletal Disorders.
